tumor - promoting cell type 1 Adipocyte - Derived Fibroblasts promote tumor progression and contribute to the desmoplastic reaction in 1 breast cancer
نویسندگان
چکیده
1 Adipocyte-Derived Fibroblasts promote tumor progression and contribute to the desmoplastic reaction in 1 breast cancer. 2 Ludivine Bochet , Camille Lehuédé, Stéphanie Dauvillier , Yuan Yuan Wang , Béatrice Dirat , 3 Victor Laurent , Cédric Dray , Romain Guiet , Isabelle Maridonneau-Parini , Sophie Le Gonidec , 4 Bettina Couderc, Ghislaine Escourrou , Philippe Valet 1,3 and Catherine Muller 1,2 * 5 6 1 Université de Toulouse, UPS, F-31077 Toulouse, France. 7 2 CNRS ; Institut de Pharmacologie et de Biologie Structurale F-31077 Toulouse, France. 8 3 Institut National de la Santé et de la Recherche Médicale, INSERM U1048, F-31432 Toulouse, France. 9 4 Institut Claudius Regaud, EA3035, F-31052 Toulouse, France. 10 5 Service d’Anatomo-Pathologie, Hôpital de Rangueil, 31403 Toulouse, France. 11 # The two first authors contributed equally to this work 12 13 Running title: ADFs, a novel tumor-promoting cell type 14
منابع مشابه
Tumor-derived osteopontin reprograms normal mammary fibroblasts to promote inflammation and tumor growth in breast cancer.
Breast tumors are characterized by an extensive desmoplastic stroma, abundantly populated by fibroblasts. Cancer-associated fibroblasts (CAF) support tumorigenesis by stimulating angiogenesis, cancer cell proliferation, and invasion. CAF also orchestrate tumor-promoting inflammation in multiple tumor types, including breast cancer. However, the mechanisms through which normal tissue fibroblasts...
متن کاملTumor Necrosis Factor a and Interleukin 11 Secreted by Malignant Breast Epithelial Cells Inhibit Adipocyte Differentiation by Selectively Down- Regulating CCAAT/Enhancer Binding Protein a and Peroxisome Proliferator-activated Receptor g: Mechanism of Desmoplastic Reaction
The dense layer of fibroblasts that accumulate around malignant breast epithelial cells (i.e., desmoplastic reaction) arises from the breast adipose tissue and provides structural and biochemical support for breast cancer. We report herein a number of epithelial-stromal interactions responsible for desmoplastic reaction in breast cancer using cultured 3T3-L1 murine fibroblasts and human adipose...
متن کاملCrosstalk between Tumor Cells and Immune System Leads to Epithelial-Mesenchymal Transition Induction and Breast Cancer Progression
Herein, we review the current findings of how a variety of accessory cells could participate in shaping the tumor microenvironment and supporting the mechanisms by which cancer cells undertake the epithelial-mesenchymal transition (EMT). EMT, a complex of phenotypic changes, promotes cancer cell invasion and creates resistance to chemotherapies. Among the accessory cells present in the EMT, imm...
متن کاملPancreatic cancer: the role of pancreatic stellate cells in tumor progression.
Pancreatic ductal adenocarcinoma is an aggressive and highly lethal disease frequently characterized by a dense stromal or desmoplastic response. Accumulating evidence exists that tumor desmoplasia plays a central role in disease progression and that e.g. activated pancreatic stellate cells (PSCs) are responsible for the excess matrix production. The mechanisms underlying the tumor versus strom...
متن کاملStromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
Fibroblasts often constitute the majority of the stromal cells within a breast carcinoma, yet the functional contributions of these cells to tumorigenesis are poorly understood. Using a coimplantation tumor xenograft model, we demonstrate that carcinoma-associated fibroblasts (CAFs) extracted from human breast carcinomas promote the growth of admixed breast carcinoma cells significantly more th...
متن کامل